Progress on the Induction of Neutralizing Antibodies Against HIV Type 1 (HIV-1)

Recent Progress toward Engineering HIV-1-Specific Neutralizing Monoclonal Antibodies

The recent discoveries of broadly potent neutralizing human monoclonal antibodies represent a new generation of antiretrovirals for the treatment and prophylaxis. Antibodies are generally considered more effective and safer and have been proved to provide passive protection against mucosal challenge in humanized mice and macaques. Several neutralizing Abs could protect animals against HIV-1 but...

Inducing Cross-Clade Neutralizing Antibodies against HIV-1 by Immunofocusing

BACKGROUND Although vaccines are important in preventing viral infections by inducing neutralizing antibodies (nAbs), HIV-1 has proven to be a difficult target and escapes humoral immunity through various mechanisms. We sought to test whether HIV-1 Env mimics may serve as immunogens. METHODOLOGY/PRINCIPAL FINDINGS Using random peptide phage display libraries, we identified the epitopes recogn...

Broadly neutralizing antibodies to prevent HIV-1.

A dvances in technology—especially single-cell antibody cloning techniques—have led to the isolation and characterization of antibodies from people with HIV infection that can neutralize many variants (1). These are referred to as broadly neutralizing antibodies (bnAbs). Such antibodies can be detected in about 25% of persons with untreated HIV-1 infection (2), reflecting a host immune response...

The Novel Study of IMODTM against HIV-1, P24 production

AIDS (Acquired Immune Deficiency Syndrome), a result of human HIV (Human Immunodeficinency Virus) infection, is one of the most troublesome world's health problems. Extensive researches to find effective drugs for its treatment are running fast in huge capacities. IMOD (Immuno-Modulator Drug) is the name of an herbal drug that has modulatory effects of immune system. As a goal of this research,...

Macrophage internal HIV - 1 is protected from neutralizing 1 antibodies